Melan-A, MART-1 (26-35) - 1 mg
- Cat.Number : AS-61011
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This native Melan-A (26-35) decapeptide is an immunodominant antigen from melanocyte/melanoma (Melan-A/MART) protein that is more efficiently recognized by tumor-infiltrating lymphocytes (TILs) of melanoma patients than the Melan-A (27-35), but has lower binding affinity and stability than the ELAGIGILTV analog.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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Citations
Profound elevation of CD8+ T cells expressing the intraepithelial lymphocyte marker CD103 (αE/β7 Integrin) in high-grade serous ovarian cancer
Gynecol Oncol . 2010 Jun 11 ; 118(3) 228 | DOI : 10.1016/j.ygyno.2010.05.016
- J. Webb