Peptides

390 MMP FRET Substrate 2 - 5 mg

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  • Cat.Number : AS-27079
  • Availability :
    In stock

Quantity

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a generic fluorogenic substrate for assaying MMPs. Abs/Em = 325/393 nm.

Specifications

Chemistry
Sequence one letter code
  • Mca-PLGL-Dap(Dnp)-AR
Sequence three letter code
  • Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-OH
Molecular Formula
  • C43H65N11O12
Molecular Mass/ Weight
  • 1094.2
Properties
Absorbance (nm)
  • 325
Emission (nm)
  • 393
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Bovine

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References

Kinetic Analysis of Matrix Metalloproteinase Activity Using Fluorogenic Triple-Helical Substrates

Biochem . 2001 Apr 18 ; 40(19) 5795 | DOI : https://doi.org/10.1021/bi0101190

  • JL. Lauer-Fields
  • et al

Biochemical characterization of human collagenase-3

J Biol Chem . 1996 Jan 19 ; 271(3) 1544 | DOI : 10.1074/jbc.271.3.1544.

  • V. Knauper
  • et al

Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).

J Biol Chem . 1994 Aug 19 ; 269 20952

  • H. Nagase
  • et al