Peptides

40Gap 27, Connexin Mimetic - 1 mg

  • Cat.Number : AS-62641
  • Availability :
    In stock

Quantity

This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.

Specifications

Chemistry
Sequence one letter code
  • SRPTEKNVFIV
Sequence three letter code
  • H-Ser-Arg-Pro-Thr-Glu-Lys-Asn-Val-Phe-Ile-Val-OH
Molecular Formula
  • C58H96N16O17
Molecular Mass/ Weight
  • 1289.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat, bovine

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Citations

Pregnancy Enhances Sustained Ca2+ Bursts and Endothelial Nitric Oxide Synthase Activation in Ovine Uterine Artery Endothelial Cells Through Increased Connexin 43 Function.

Biol Reprod . 2009 Sep 09 ; 82(1) 66 | DOI : 10.1095/biolreprod.109.078253

  • FX. Yi

The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent.

Cardio Res . 2014 Mar 20 ; 103(1) 72 | DOI : 10.1093/cvr/cvu066.

  • W. Srisakuldee

References

Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery

British J Pharmacol . 2005 Jan 29 ; 144(1) 108 | DOI : https://doi.org/10.1038/sj.bjp.0706046

  • A. Chaytor
  • et al