IMG-EN-AS-62642-01.jpg
Peptides

43Gap 27, Connexin (200-210) (human, mouse, rat) - 1 mg

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  • Cat.Number : AS-62642
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This peptide corresponds to the GAP27 domain of connexin. Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. Gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. This intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. Calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. This synthetic connexin-mimetic peptide, Gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. It was concluded that gap-junctional communication is necessary for proper bone remodeling.

Specifications

Chemistry
Sequence one letter code
  • SRPTEKTIFII
Sequence three letter code
  • H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH
CAS registry number
  • 198284-64-9
Molecular Formula
  • C60H101N15O17
Molecular Mass/ Weight
  • 1304.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat

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Citations

Pregnancy Enhances Sustained Ca2+ Bursts and Endothelial Nitric Oxide Synthase Activation in Ovine Uterine Artery Endothelial Cells Through Increased Connexin 43 Function.

Biol Reprod . 2009 Sep 09 ; 82(1) 66 | DOI : 10.1095/biolreprod.109.078253

  • FX. Yi

References

Connexin mimetic peptides reversibly inhibit Ca2+signaling through gap junctions in airway cells

J Physiol Lung Cell Mol Physiol . 2000 Oct 01 ; 279(4) L623 | DOI : https://doi.org/10.1152/ajplung.2000.279.4.L623

  • S. Boitano
  • H. Evans

Connexin-mimetic peptide Gap 27 decreases osteoclastic activity

BMC Musculoskel Disord . 2001 Dec 05 ; 2 10 | DOI : 10.1186/1471-2474-2-10

  • J. Ilvesaro
  • et al

Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery

British J Pharmacol . 2005 Jan 29 ; 144(1) 108 | DOI : https://doi.org/10.1038/sj.bjp.0706046

  • A. Chaytor
  • et al

Peptide inhibitors of intercellular communication

Am J Physiol Lung Cell Mol Physiol . 2000 Oct 01 ; 279(4) 619 | DOI : https://doi.org/10.1152/ajplung.2000.279.4.L619

  • V. Berthoud
  • et al