IMG-EN-AS-60576-01-01.jpg
Peptides

520 MMP FRET Substrate 9 - 0.1 mg

$214.00
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  • Cat.Number : AS-60576-01
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    In stock

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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-1, 2, 7, 8, 12 and 13 activities, Abs/Em = 494/521 nm.

Specifications

Chemistry
Sequence one letter code
  • QXL® 520-RPLALWRK(5-FAM)-NH2
Sequence three letter code
  • QXL® 520-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Lys(5-FAM)-NH2
Molecular Mass/ Weight
  • 1888.1
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy

Scientific Reports . 2018 Apr 11 ; 8 5810 | DOI : https://doi.org/10.1038/s41598-018-24144-1

  • MA. Freeberg
  • et al