Peptides

[Ala13]-Apelin-13 - 1 mg

$101.00
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  • Cat.Number : AS-61078
  • Availability :
    In stock

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Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77).
Apelin -13 is a vasoactive peptide and one of the most potent endogenous inotropic agents known. It is one of the active peptide fragments resulting from maturation of preproapelin. It is suggested that Apelin-13 could be a competitive agonist to the apelin receptor, which is a class A G-protein coupled receptor and is a putative target for treatment of cardiovascular and metabolic diseases. Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • QRPRLSHKGPMPA
Sequence three letter code
  • H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH
CAS registry number
  • 568565-11-7
Molecular Formula
  • C63H107N23O16S
Molecular Mass/ Weight
  • 1474.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, mouse, bovine, rat

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References

Discovery of a Competitive Apelin Receptor (APJ) Antagonist

Chem Med Chem . 2011 Jun 06 ; 6(6) 6(6) | DOI : https://doi.org/10.1002/cmdc.201100069

  • NJM. Macaluso
  • et al

Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action

Endocrinol . 2005 Jan 01 ; 146(1) 231 | DOI : https://doi.org/10.1210/en.2004-0359

  • D. Lee
  • et al