Peptides

alpha-Gliadin (31-43) - 1 mg

  • Cat.Number : AS-65106
  • Availability :
    In stock

Quantity

This peptide is derived from gliadin wheat protein residues 31-43. It elicits an innate immune response by upregulating expression of interleukin (IL)-15 and cyclooxygenase (COX)-2. This peptide also promotes expression of CD25 on monocytes and macrophages, expression of CD83 on dendritic cells, and p38 MAP kinase activation. Treatment with this peptide allows immunodominant epitopes (57-68 and 62-75) to induce T-cell activation and enterocyte apoptosis.

Specifications

Chemistry
Sequence one letter code
  • LGQQQPFPPQQPY
Sequence three letter code
  • H-Leu-Gly-Gln-Gln-Gln-Pro-Phe-Pro-Pro-Gln-Gln-Pro-Tyr-OH
Molecular Formula
  • C71H102N18O20
Molecular Mass/ Weight
  • 1527.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • wheat

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References

Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease

Lancet . 2003 Jul 05 ; 362(9377) 30 | DOI : https://doi.org/10.1016/S0140-6736(03)13803-2

  • L. Maiuri
  • et al

Identification of a peptide from α-gliadin resistant to digestive enzymes: Implications for celiac disease

J Chromatogr B . 2007 Aug 15 ; 855(2) 236 | DOI : https://doi.org/10.1016/j.jchromb.2007.05.009

  • G. Mamone
  • et al

Multiantigenic Peptides as Standards in Immunoassays for Complex Proteins: Use of LGQQQPFPPQQPY in an Enzyme-Linked Immunosorbent Assay for Gluten

Anal Biochem . 2001 May 15 ; 292(2) 301 | DOI : https://doi.org/10.1006/abio.2001.5037

  • S. Chambers
  • et al