Peptides

Angiotensin I, human, ClearPoint™ Val Ile labeled (13C and 15N) - 0.1 mg

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  • Cat.Number : AS-65140
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This peptide is angiontensin I (Ang I) with valine and isoleucine universally labeled with 13C and 15N. Ang I is a precursor to Ang II, which has been implicated in cardiovascular functions, cell proliferation, fibrosis, and apoptosis. The 10-mer Ang I peptide is converted to Ang II through the cleavage of the Phe8-His9 bond of Ang I by angiotensin-converting enzyme (ACE) or human chymase.

Specifications

Chemistry
Sequence one letter code
  • DR-V*-Y-I*-HPFHL [Val* = Val(U-13C5,15N); Ile* = Ile(U-13C6,15N)]
Sequence three letter code
  • H-Asp-Arg-Val*-Tyr-Ile*-His-Pro-Phe-His-Leu-OH [Val* = Val(U-13C5,15N); Ile* = Ile(U-13C6,15N)]
Molecular Formula
  • C62H89N17O14
Molecular Mass/ Weight
  • 1309.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II

JBC . 2004 Jun 01 ; 279 32339 | DOI : 10.1074/jbc.M405576200

  • A. Lundequist

Distinct Multisite Synergistic Interactions Determine Substrate Specificities of Human Chymase and Rat Chymase-1 for Angiotensin II Formation and Degradation

JBC . 1997 Jan 31 ; 272 2963 | DOI : 10.1074/jbc.272.5.2963

  • S. Sanker
  • et al