Peptides

Angiotensin I, human

  • Cat.Number : AS-20627
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This human Angiotensin I (Ang I) sequence also corresponds to horse, sheep, pig, and rat Ang I. Ang I is cleaved to Ang II by the angiotensin-converting enzyme (ACE). There is also evidence for non-angiotensin-converting enzyme-dependent conversion of Ang I to Ang II. Human chymase efficiently converts the 10-mer Ang I to the 8-mer hormone Ang II by splitting the Phe8-His9 bond in Ang I.

Specifications

Chemistry
Sequence one letter code
  • DRVYIHPFHL
Sequence three letter code
  • H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH
CAS registry number
  • 484-42-4
Molecular Formula
  • C62H89N17O14
Molecular Mass/ Weight
  • 1296.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Selective photodynamic therapy by targeted Verteporfin delivery to experimental choroidal neovascularization mediated by a homing peptide to vascular endothelial growth factor receptor-2.

Arch Ophthalmol . 2004 Jul 01 ; 122(7) 1002 | DOI : 10.1001/archopht.122.7.1002

  • RZ. Renno

Rapid online nonenzymatic protein digestion combining microwave heating acid hydrolysis and electrochemical oxidation.

Anal Chem . 2010 Dec 07 ; 83(1) 359 | DOI : 10.1021/ac1024705

  • F. Basile

The use of acetone as a substitute for acetonitrile in analysis of peptides by liquid chromatography/electrospray ionization mass spectrometry.

Rapid Comm Mass Spectrom . 2010 Jan 01 ; 24(1) 6 | DOI : 10.1002/rcm.4352

  • T. Keppel

Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation.

Anal Chem . 2009 Jan 15 ; 81(2) 782 | DOI : 10.1021/ac802015m

  • N. Rauniyar

References

Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II

JBC . 2004 Jun 01 ; 279 32339 | DOI : 10.1074/jbc.M405576200

  • A. Lundequist

Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor

Am J Physiol Lung Cell Mol Physiol . 2004 Sep 01 ; 287 L559 | DOI : https://doi.org/10.1152/ajplung.00312.2003

  • A. Kinoshita
  • et al

Distinct Multisite Synergistic Interactions Determine Substrate Specificities of Human Chymase and Rat Chymase-1 for Angiotensin II Formation and Degradation

JBC . 1997 Jan 31 ; 272 2963 | DOI : 10.1074/jbc.272.5.2963

  • S. Sanker
  • et al