Peptides

Angiotensin II, Biotin-LC - 5 mg

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  • Cat.Number : AS-60276-5
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This octapeptide Angiotensin II, DRVYIHPF, is biotinylated on the N-terminus via an LC (long chain, also known as 6-Aminohexanoyl, 6-Aminocaproyl or Ahx) linker. It can be used in ELISA assay. Angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.

Specifications

Chemistry
Sequence one letter code
  • Biotin-LC-DRVYIHPF
Sequence three letter code
  • Biotin-LC-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Molecular Formula
  • C66H94N16O15S
Molecular Mass/ Weight
  • 1385.7
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse

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Citations

Qdot nanocrystal conjugates conjugated to bombesin or ANG II label the cognate G protein-coupled receptor in living cells.

Am J Physiol-Cell Physiol . 2005 Oct 19 ; 290(3) C728 | DOI : 10.1152/ajpcell.00310.2005.

  • SH. Young
  • E. Rozengurt

References

Angiotensin converting enzyme-like activity in tissues from the river lamprey or lampern, Lampetra fluviatilis, acclimated to freshwater and seawater

Gen Comp Endocrinol . 2002 Jun 01 ; 127 (1) | DOI : https://doi.org/10.1016/S0016-6480(02)00014-X

  • C Cobb,

Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II

JBC . 2004 Jun 01 ; 279 32339 | DOI : 10.1074/jbc.M405576200

  • A. Lundequist

Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart.

JBC . 1991 Oct 15 ; 266 19192 | DOI : PMID: 1918036

  • A. Kinoshita

Comparison of the solution structures of angiotensin I & II: Implication for structure-function relationship

Eur J Biochem . 2003 Apr 22 ; 270 2163 | DOI : https://doi.org/10.1046/j.1432-1033.2003.03573.x

  • G. Spyroulias