IMG-EN-AS-64805-01.jpg
Peptides

Angiotensin II, human, ClearPoint™ Ile labeled (13C and 15N) - 0.1 mg

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  • Cat.Number : AS-64805
  • Availability :
    In stock

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This peptide is angiontensin II (Ang II) with Isoleucine universally labeled with 13C and 15N. The octapeptide angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed through cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.

Specifications

Chemistry
Sequence one letter code
  • DRVY-I*-HPF [I*= I(U13C6,15N)]
Sequence three letter code
  • H-Asp-Arg-Val-Tyr-*Ile-His-Pro-Phe-OH [Ile*= Ile(U13C6,15N)]
Molecular Formula
  • C50H71N13O12
Molecular Mass/ Weight
  • 1053.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Angiotensin converting enzyme-like activity in tissues from the river lamprey or lampern, Lampetra fluviatilis, acclimated to freshwater and seawater

Gen Comp Endocrinol . 2002 Jun 01 ; 127 (1) | DOI : https://doi.org/10.1016/S0016-6480(02)00014-X

  • C Cobb,

Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II

JBC . 2004 Jun 01 ; 279 32339 | DOI : 10.1074/jbc.M405576200

  • A. Lundequist

Comparison of the solution structures of angiotensin I & II: Implication for structure-function relationship

Eur J Biochem . 2003 Apr 22 ; 270 2163 | DOI : https://doi.org/10.1046/j.1432-1033.2003.03573.x

  • G. Spyroulias

Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart.

JBC . 1991 Oct 15 ; 266 19192

  • A. Kinoshita

Angiotensin converting enzyme-like activity in tissues from the river lamprey or lampern, Lampetra fluviatilis, acclimated to freshwater and seawater

Gen Comp Endocrinol . 2002 Jun 01 ; 127(1) 8 | DOI : https://doi.org/10.1016/S0016-6480(02)00014-X

  • C Cobb,
  • et al

Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin I

J Biol Chem . 2004 Jul 01 ; 279(31) 32339 | DOI : https://doi.org/10.1074/jbc.M405576200

  • A. Lundequist
  • et al

Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart.

J Biol Chem . 1991 Oct 01 ; 266(29) 19192 | DOI : https://doi.org/10.1016/S0021-9258(18)54981-4

  • A. Kinoshita
  • et al