Peptides

Angiotensin II Phosphate - 1 mg

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  • Cat.Number : AS-24520
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This is a tyrosine phosphorylated angiotensin II peptide with a substrate sequence specificity for chymase to act. This is an octapeptide hormone that is formed as a result of the action of human heart chymase, a chymotrypsin-like serine protease on the Phe-His bond of Angiotensin I. The ideal susbtrate for human heart chymase should contain this peptide sequence, and has been demonstrated that the Pro-Phe sequence in P2-P1 positions of peptide substrates is highly favored by leukocyte chymotrypsin-like proteinases such as chymases and cathepsin G.

Specifications

Chemistry
Sequence one letter code
  • DRV-pY-IHPF
Sequence three letter code
  • H-Asp-Arg-Val-pTyr-Ile-His-Pro-Phe-OH
Molecular Formula
  • C50H72N13O15P
Molecular Mass/ Weight
  • 1126.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse

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Citations

Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociationof peptides in a quadrupole ion trapwith selective IRMPD of phosphopeptides.

J Am Soc Mass Spectrom . 2004 Nov 01 ; 15(11) 1581 | DOI : 10.1016/j.jasms.2004.07.016

  • MC. Crowe

Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociation of peptides in a quadrupole ion trap with selective IRMPD of phosphopeptides.

J. Am. Soc. for Mass Spectrom . 2004 Nov 01 ; 15(11) 1581 | DOI : 10.1016/j.jasms.2004.07.016.

  • MC. Crowe
  • JS. Brodbelt

Angiotensin II–Acetylcholine noncovalent complexes analyzed with MALDI–Ion mobility–TOF MS.

J Biomol Tech. . 2003 Mar 01 ; 14(1) 1 | DOI : PMC2279889

  • AS. Woods

References

Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart.

JBC . 1991 Oct 15 ; 266 19192 | DOI : PMID: 1918036

  • A. Kinoshita

Specificity of T‐cell protein tyrosine phosphatase toward phosphorylated synthetic peptides

Eur J Biochem . 1993 Jan 01 ; 211 1 | DOI : https://doi.org/10.1111/j.1432-1033.1993.tb19897.x

  • M. Ruzzene
  • et al