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Peptides

Angiotensin II

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  • Cat.Number : AS-20633
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The octapeptide angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.

Specifications

Chemistry
Sequence one letter code
  • DRVYIHPF
Sequence three letter code
  • H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
CAS registry number
  • 4474-91-3
Molecular Formula
  • C50H71N13O12
Molecular Mass/ Weight
  • 1046.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Differentiating N-terminal aspartic and isoaspartic acid residues in peptides.

Anal Chem . 2011 Aug 16 ; 83(17) 6675 | DOI : 10.1021/ac201223d.

  • NP. Sargaeva

Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase–endothelial nitric oxide synthase pathway in rats.

Clin Exp Pharmacol Physiol . 2011 Jan 01 ; 38(1) 55 | DOI : 10.1111/j.1440-1681.2010.05461.x

  • C. Zhang

Enhanced ion signals in desorption electrospray ionization using surfactant spray solutions.

J Am Soc Mass Spectrom . 2010 Apr 08 ; 21(8) 1423 | DOI : 10.1016/j.jasms.2010.04.001

  • A. Badu-Tawaih
  • RG. Cooks

Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway.

J Cell Physiol . 2010 Oct 01 ; 225(1) 168 | DOI : 10.1002/jcp.22209

  • Y. Zhao

Fragmentation of Singly Protonated Peptides via Interaction with Metastable Rare Gas Atoms.

Anal Chem . 2009 Jan 15 ; 81(2) 725 | DOI : 10.1021/ac802214e

  • V. Berkout

Blockade of angiotensin II attenuates VEGF-mediated blood–retinal barrier breakdown in diabetic retinopathy.

J Cerebral Blood Flow Metab . 2008 Dec 24 ; 29(3) 621 | DOI : 10.1038/jcbfm.2008.154

  • J. Kim

Chromogenic cross-linker for the characterization of protein structure by infrared multiphoton dissociation mass spectrometry.

Anal Chem . 2008 Jun 03 ; 80(13) 4807 | DOI : 10.1021/ac800625x

  • M. Gardner

Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells.

Acta Biochim Biophys Sin . 2008 Apr 01 ; 40(4) 304 | DOI : 10.1111/j.1745-7270.2008.00402.x

  • Y. Zhao

Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and β-cells.

Endocrinology . 2007 Feb 15 ; 148(5) 2198 | DOI : 10.1210/en.2006-1358

  • G. Chipitsyna

Site-Specific Pyrolysis Induced Cleavage at Aspartic Acid Residue in Peptides and Proteins

J Proteome Res . 2011 Sep 20 ; 6(5) 1700 | DOI : 10.1021/pr060648w

  • S. Zhang

On-Probe Pyrolysis Desorption Electrospray Ionization (DESI) Mass Spectrometry for the Analysis of Non-Volatile Pyrolysis Products

J Anal Appl Pyrolysis . 2009 Oct 23 ; 80(2) 353 | DOI : 10.1016/j.jaap.2007.04.005

  • S. Zhang

Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociationof peptides in a quadrupole ion trapwith selective IRMPD of phosphopeptides.

J Am Soc Mass Spectrom . 2004 Nov 01 ; 15(11) 1581 | DOI : 10.1016/j.jasms.2004.07.016

  • MC. Crowe

Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation.

Anal Chem . 2009 Jan 15 ; 81(2) 782 | DOI : 10.1021/ac802015m

  • N. Rauniyar

Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociation of peptides in a quadrupole ion trap with selective IRMPD of phosphopeptides.

J. Am. Soc. for Mass Spectrom . 2004 Nov 01 ; 15(11) 1581 | DOI : 10.1016/j.jasms.2004.07.016.

  • MC. Crowe
  • JS. Brodbelt

Angiotensin II–Acetylcholine noncovalent complexes analyzed with MALDI–Ion mobility–TOF MS.

J Biomol Tech. . 2003 Mar 01 ; 14(1) 1 | DOI : PMC2279889

  • AS. Woods

Site-Specific Pyrolysis-Induced Cleavage at Aspartic Acid Residue in Peptides and Proteins

J Proteome Res. . 2007 May 01 ; 6(5) 1700 | DOI : 10.1021/pr060648w

  • S. Zhang

References

Angiotensin converting enzyme-like activity in tissues from the river lamprey or lampern, Lampetra fluviatilis, acclimated to freshwater and seawater

Gen Comp Endocrinol . 2002 Jun 01 ; 127 (1) | DOI : https://doi.org/10.1016/S0016-6480(02)00014-X

  • C Cobb,

Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II

JBC . 2004 Jun 01 ; 279 32339 | DOI : 10.1074/jbc.M405576200

  • A. Lundequist

Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart.

JBC . 1991 Oct 15 ; 266 19192 | DOI : PMID: 1918036

  • A. Kinoshita

Comparison of the solution structures of angiotensin I & II: Implication for structure-function relationship

Eur J Biochem . 2003 Apr 22 ; 270 2163 | DOI : https://doi.org/10.1046/j.1432-1033.2003.03573.x

  • G. Spyroulias