IMG-EN-AS-62145-01.jpg
Peptides

[Asn23]-beta-Amyloid (1-40), Iowa Mutation - 0.5 mg

$275.00
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  • Cat.Number : AS-62145
  • Availability :
    In stock

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Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFAENVGSNKGAIIGLMVGGVV
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asn-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
CAS registry number
  • 374796-72-2
Molecular Formula
  • C194H296N54O57S
Molecular Mass/ Weight
  • 4329.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

Ann Neurol . 2001 Jun 01 ; 49(6) 697 | DOI : https://doi.org/10.1002/ana.1009

  • T. Grabowski
  • et al

Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein

J Biol Chem . 2001 Aug 01 ; 276(35) 32860 | DOI : https://doi.org/10.1074/jbc.M104135200

  • W. Van Nostrand
  • et al