Peptides

Beta-Amyloid (1-42)

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  • Cat.Number : AS-20276
  • Availability :
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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS registry number
  • 107761-42-2
Molecular Formula
  • C203H311N55O60S
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Peptide Content
  • ≥ 60%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease

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Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics

MCP . 2015 Sep 30 ; 14(12) 3173 | DOI : https://doi.org/10.1074/mcp.M115.053926

  • H. Bell-Temin

Tailoring the antibody response to aggregated Aß using novel Alzheimer-Vaccines

PLoS One . 2015 Jan 22 ; 10(1) e0115237 | DOI : 10.1371/journal.pone.0115237

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LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice

Neuropharmacology . 2015 Feb 14 ; 93 243 | DOI : 10.1016/j.neuropharm.2015.02.003

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Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

Infect Immun. . 2014 Nov 24 ; 83(2) 693 | DOI : 10.1128/IAI.02370-14

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Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APPLondon Mice

J Neurosci . 2014 Aug 27 ; 34(35) 11621 | DOI : 10.1523/JNEUROSCI.1405-14.2014

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Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause

Brain . 2013 May 01 ; 136(Pt 5) 1432 | DOI : 10.1093/brain/awt046

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Glutamine Acts as a Neuroprotectant against DNA Damage, Beta-Amyloid and H2O2-Induced Stress

PLoS One . 2012 Mar 08 ; 7(3) e33177 | DOI : 10.1371/journal.pone.0033177

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A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

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Microglial Amyloid-1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease

Int J Alzheimers Dis . 2012 Feb 24 ; 2012 11 | DOI : http://dx.doi.org/10.1155/2012/685739

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Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

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Allosteric modulator desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-Amyloid 1–42 peptide

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S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide

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A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's Disease

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Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer's Disease

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Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease

J Neurochem . 2010 Apr 14 ; 113(4) | DOI : https://doi.org/10.1111/j.1471-4159.2010.06661.x

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Gelsolin Restores A-Induced Alterations in Choroid Plexus Epithelium

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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

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Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome

Neurosci Lett . 2010 Feb 05 ; 470(1) 81 | DOI : https://doi.org/10.1016/j.neulet.2009.12.062

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Mutant presenilin 1 increases the expression and activity of BACE1

JBC . 2009 Feb 05 ; 284 9027 | DOI : 10.1074/jbc.M805685200

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β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

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Amyloid-dependent triosphosphate isomerase nitrotyrosination induces glycation and tau fibrillation

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Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

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Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

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Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

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Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B)

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Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats

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CLAC Binds to Amyloid β Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils

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Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

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The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cel death by inhibiting the formation of β-derived diffusible neurotoxic ligands

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Vitamin E Prevents Alzheimer's Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production.

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Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation

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Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease

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Microglial Amyloid-β1-40 Phagocytosis Dysfunction is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease

Int J Alz Dis . 2012 May 08 ; 2012 685739 | DOI : https://doi.org/10.1155/2012/685739

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Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium

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Competitive electrochemical immunosensor for amyloid-beta 1-42 detection based on gold nanostructurated screen-printed carbon electrodes.

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Protection against beta-amyloid induced apoptosis by peptides interacting with beta-amyloid.

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β -Secretase-Cleaved Amyloid Precursor Protein Accumulates at Actin Inclusions Induced in Neurons by Stress or Amyloid β : A Feedforward Mechanism for Alzheimer’s Disease

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Quantification of Amyloid-β in Plasma by Simple and Highly Sensitive Immunoaffinity Enrichment and LC-MS/MS Assay

J Applied Lab Med . 2021 Jul 01 ; 6(4) 834 | DOI : https://doi-org.lib-proxy.fullerton.edu/10.1093/jalm/jfaa225

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  • et al

References

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Soluble Amyloid Aβ-(1–40) Exists as a Stable Dimer at Low Concentrations

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