Beta-Amyloid (1-42)
- Cat.Number : AS-20276
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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit.
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Citations
Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease
Inorg Chem . 2016 Apr 27 ; 55(10) 5000 | DOI : 10.1021/acs.inorgchem.6b00525
- J. Derrick
Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics
MCP . 2015 Sep 30 ; 14(12) 3173 | DOI : https://doi.org/10.1074/mcp.M115.053926
- H. Bell-Temin
Tailoring the antibody response to aggregated Aß using novel Alzheimer-Vaccines
PLoS One . 2015 Jan 22 ; 10(1) e0115237 | DOI : 10.1371/journal.pone.0115237
- M. Mandler
LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice
Neuropharmacology . 2015 Feb 14 ; 93 243 | DOI : 10.1016/j.neuropharm.2015.02.003
- SY. Hung
Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli
Infect Immun. . 2014 Nov 24 ; 83(2) 693 | DOI : 10.1128/IAI.02370-14
- GJ. Rapsinski
Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APPLondon Mice
J Neurosci . 2014 Aug 27 ; 34(35) 11621 | DOI : 10.1523/JNEUROSCI.1405-14.2014
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Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause
Brain . 2013 May 01 ; 136(Pt 5) 1432 | DOI : 10.1093/brain/awt046
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Glutamine Acts as a Neuroprotectant against DNA Damage, Beta-Amyloid and H2O2-Induced Stress
PLoS One . 2012 Mar 08 ; 7(3) e33177 | DOI : 10.1371/journal.pone.0033177
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A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization
PLoS One . 2012 Mar 19 ; 7(3) e31869 | DOI : https://doi.org/10.1371/journal.pone.0031869
- RA. Orlando
Microglial Amyloid-1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease
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Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation
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A screening UHPLC–MS/MS method for the analysis of amyloid peptides in cerebrospinal fluid of preclinical species
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Allosteric modulator desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-Amyloid 1–42 peptide
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Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo
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HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures
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Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer's Disease
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Prostaglandin E2 reduces amyloid β-induced phagocytosis in cultured rat microglia
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CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia
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Elevation of β-Amyloid 1-42 Autoantibodies in the Blood of Amnestic Patients With Mild Cognitive Impairment
Arch Neurol . 2010 Jul 01 ; 67(7) 867 | DOI : 10.1001/archneurol.2010.137
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Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease
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Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer's disease
Hippocampus . 2011 Jun 24 ; 21(7) | DOI : https://doi.org/10.1002/hipo.20790
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Gelsolin Restores A-Induced Alterations in Choroid Plexus Epithelium
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Two-Photon and Time-Resolved Fluorescence Conformational Studies of Aggregation in Amyloid Peptides
J Phy CehmB . 2010 Apr 29 ; 114 7112 | DOI : https://doi.org/10.1021/jp101496y
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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases
J Neural Transm . 2010 Jan 01 ; 117(1) 85 | DOI : 10.1007/s00702-009-0314-x
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Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome
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Mutant presenilin 1 increases the expression and activity of BACE1
JBC . 2009 Feb 05 ; 284 9027 | DOI : 10.1074/jbc.M805685200
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β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution
JBC . 2009 Feb 24 ; 284 10639 | DOI : 10.1074/jbc.M806508200
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Amyloid-dependent triosphosphate isomerase nitrotyrosination induces glycation and tau fibrillation
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Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier
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Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism
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Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B)
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Aβ 1-42 Induces Mild Endoplasmic Reticulum Stress in an Aggregation State–Dependent Manner
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Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-Aβ antibody
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Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease
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CLAC Binds to Amyloid β Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils
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Aβ-polyacrolein aggregates: Novel mechanism of plastic formation in senile plaques
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Epitope and isotope specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology
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Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis
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The hydrophobic environment of Met35 of Alzheimer's Aβ(1–42) is important for the neurotoxic and oxidative properties of the peptide
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Vitamin E Prevents Alzheimer's Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production.
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Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation
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Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease
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Interaction between β-amyloid and lens αB-crystallin
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N‐terminal truncated pyroglutamyl β amyloid peptide Aβpy3‐42 shows a faster aggregation kinetics than the full‐length Aβ1‐42.
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β-Amyloid is different in normal aging and in Alzheimer disease.
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Microchip electrophoresis profiling of Aβ peptides in the cerebrospinal fluid of patients with Alzheimer’s disease.
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Formation of Amyloids by Aβ-(1–42) on NGF-differentiated PC12 Cells: Roles of Gangliosides and Cholesterol.
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N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia.
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Protection against β-Amyloid-induced Apoptosis by Peptides Interacting with β-Amyloid.
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Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E.
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Competitive electrochemical immunosensor for amyloid-beta 1-42 detection based on gold nanostructurated screen-printed carbon electrodes.
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Protection against beta-amyloid induced apoptosis by peptides interacting with beta-amyloid.
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β -Secretase-Cleaved Amyloid Precursor Protein Accumulates at Actin Inclusions Induced in Neurons by Stress or Amyloid β : A Feedforward Mechanism for Alzheimer’s Disease
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Quantification of Amyloid-β in Plasma by Simple and Highly Sensitive Immunoaffinity Enrichment and LC-MS/MS Assay
J Applied Lab Med . 2021 Jul 01 ; 6(4) 834 | DOI : https://doi-org.lib-proxy.fullerton.edu/10.1093/jalm/jfaa225
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