IMG-EN-AS-24015-01.jpg
Peptides

B-type Natriuretic Peptide, BNP-32, human

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  • Cat.Number : AS-24015
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B-type (Brain) natriuretic peptide (BNP) is a 32 amino acid hormone initially isolated from the porcine brain, but mainly produced by the heart ventricles. It is released from a prepro-hormone after cleavage of a signal peptide and further processing by a protease with a conserved recognition sequence (RXXR-S). This cleavage generated NT-proBNP (76aa) and the biologically active 32aa BNP-32, which are secreted in blood in equimolar concentrations.
BNP-32 is secreted by cardiomyocytes in response to myocardial stretch and overload resulting from hypervolaemia and increased blood pressure. It is known to oppose the renin-angiotensin-aldosterone system and exert vasodilatory effects. This 32 amino acid peptide contains a 17 amino acid ring structure that is common to all natriuretic peptides.

Specifications

Chemistry
Sequence one letter code
  • SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (Disulfide bridge: 10-26)
Sequence three letter code
  • H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH (Disulfide bridge: 10-26)
CAS registry number
  • 114471-18-0
Molecular Formula
  • C143H244N50O42S4
Molecular Mass/ Weight
  • 3464.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

B-type Natriuretic Peptide: A Review of Its Diagnostic, Prognostic, and Therapeutic Monitoring Value in Heart Failure for Primary Care Physicians

J Am Board Fam Prac . 2003 Jul 08 ; 16(4) 327 | DOI : https://doi.org/10.3122/jabfm.16.4.327

  • R. Cardarelli
  • et al

A new natriuretic peptide in porcine brain

Nature . 1988 Mar 03 ; 332 78 | DOI : 10.1038/332078a0

  • T. Sudoh
  • et al

Natriuretic Peptides—Relevance in Cardiovascular Disease

JAMA . 1998 Dec 16 ; 280(23) 1983 | DOI : 10.1001/jama.280.23.1983

  • B. Cheung
  • et al

Fortnightly Review: Ten years of natriuretic peptide research: a new dawn for their diagnostic and therapeutic use?

BMJ . 1994 Jun 18 ; 308 1615 | DOI : https://doi.org/10.1136/bmj.308.6944.1615

  • A. Struthers