IMG-EN-AS-63774-01.jpg
Peptides

BDC2.5 Mimotope 1040-63 - 1 mg

$126.00
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  • Cat.Number : AS-63774
  • Availability :
    In stock

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The TCR transgenic model (BDC2.5) mimitope was used in type 1 diabetes (T1D) study. T1D is an autoimmune disease in which T cells mediate damage to pancreatic islet b cells. T1D is caused by autoreactive T cell destruction of insulin-producing cells. BDC2.5 mimotope was utilized to support the study on antigen presentation of antigenic peptides to islet autoantigen-specific T cells.

Specifications

Chemistry
Sequence one letter code
  • RTRPLWVRME
Sequence three letter code
  • H-Arg-Thr-Arg-Pro-Leu-Trp-Val-Arg-Met-Glu-OH
Molecular Formula
  • C59H98N20O14S
Molecular Mass/ Weight
  • 1343.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse

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References

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

J Clin Invest. . 2007 Dec 03 ; 117 3857 | DOI : 10.1172/JCI32405

  • C. Hu
  • et al

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand

J Immunol . 2003 Dec 15 ; 171 3857 | DOI : https://doi.org/10.4049/jimmunol.171.12.6954

  • N. Martin-Orozco
  • et al