Peptides

Beta-Amyloid (1-40) Binding Peptide, Biotin-labeled - 1 mg

$235.00
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  • Cat.Number : AS-62427
  • Availability :
    In stock

Quantity

This 20 amino acid peptide binds to the amyloid form of beta-Amyloid (1-40) but not to monomeric beta-Amyloid (1-40). This sequence represents new potential carrier molecules to deliver medicines to amyloid plaques in AD patients and to image plaques in AD brains. The ability to directly target reagents to the amyloid form of the beta-Amyloid peptide may allow the delivery of neuroprotective agents to make amyloid plaques less toxic, the delivery of amyloid-destroying molecules to eliminate plaques, or the delivery of reagents to prevent amyloid plaque formation. This sequence is biotinylated on the N-terminus.

Specifications

Chemistry
Sequence one letter code
  • Biotin-DWGKGGRWRLWPGASGKTEA
Sequence three letter code
  • Biotin-Asp-Trp-Gly-Lys-Gly-Gly-Arg-Trp-Arg-Leu-Trp-Pro-Gly-Ala-Ser-Gly-Lys-Thr-Glu-Ala-OH
Molecular Formula
  • C110H161N33O29S1
Molecular Mass/ Weight
  • 2441.9
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Identification of peptides that specifically bind Aβ1–40 amyloid in vitro and amyloid plaques in Alzheimer's disease brain using phage display

Neurobiol Dis . 2003 Oct 01 ; 14(1) 146 | DOI : https://doi.org/10.1016/S0969-9961(03)00105-0

  • C. Kang
  • et al