Peptides

Cathepsin S Substrate - 1 mg

$131.00
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  • Cat.Number : AS-61859
  • Availability :
    In stock

Quantity

Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.
This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.

Specifications

Chemistry
Sequence one letter code
  • Ac-KQKLR-AMC
Sequence three letter code
  • Ac-Lys-Gln-Lys-Leu-Arg-AMC
CAS registry number
  • 1135686-31-5
Molecular Formula
  • C41H66N12O9
Molecular Mass/ Weight
  • 871.1
Properties
Absorbance (nm)
  • 354
Emission (nm)
  • 442
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

A parasite cysteine protease is key to host protein degradation and iron acquisition.

J Biol Chem . 2008 Aug 13 ; 283(43) 28934 | DOI : 10.1074/jbc.M805824200

  • T. O'Brien

References

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

J Bone Miner Res . 2001 Oct 01 ; 16(10) 1739 | DOI : https://doi.org/10.1359/jbmr.2001.16.10.1739

  • G. Stroup
  • et al