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Peptides

CKS-17 (dimer), MN10021 - 1 mg

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  • Cat.Number : AS-64578-
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    In stock

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A dimer of CKS-17 has a natural occurring cysteine at the carboxyl terminus (where it occurs in the retroviral peptides on which CKS-17 is based) and dimerization is accomplished by cysteine-disulfide linkage. CKS-17 is a synthetic retroviral envelope heptadecapeptide corresponding to a region highly conserved in retroviral transmembrane proteins such as pl5E. The CKS-17 peptide has been previously shown to inhibit monocyte superoxide production, natural killer cell activity, polyclonal B-cell activation, and monocyte-mediated killing by inactivation of interleukin-1.

Specifications

Chemistry
Sequence one letter code
  • LQNRRGLDLLFLKEGGLC (dimer)
Sequence three letter code
  • H-Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu-Cys-OH
CAS registry number
  • 99273-04-8
Molecular Formula
  • C87H148N26O24(monomer)
Molecular Mass/ Weight
  • 4088.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • murine leukemia virus, retroviruses

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References

Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: Immunosuppression, immunogenicity, and relation to immunosuppressive tumor products

Cancer Immunol Immunother . 1989 Mar 01 ; 30 113

  • M. Nelson
  • et al