Cls Substrate, C2 (Abz/Dnp) - 1 mg
- Cat.Number : AS-61315
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This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.
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Citations
Antimicrobial peptide conformation as a structural determinant of omptin protease specificity
J Bacteriol . 2015 Sep 08 ; 197 22 | DOI : 10.1128/JB.00469-15
- RJ. Brannon
OmpT outer membrane proteases of enterohemorrhagic and enteropathogenic Escherichia coli contribute differently to the degradation ofhuman LL-37
Infect Immun . 2011 Dec 05 ; 80(2) 483 | DOI : 10.1128/IAI.05674-11
- JL. Thomassin
References
Cleavage of C2 by C1̄s̄ into the antigenically distinct fragments C2a and C2b: Demonstration of binding of C2b to C4b
PNAS . 1977 Jul 01 ; 74(7) 2998 | DOI : https://doi.org/10.1073/pnas.74.7.2998
- S. Nagasawa
- R. Stroud
Elucidation of the Substrate Specificity of the C1s Protease of the Classical Complement Pathway
J Biol Chem . 2005 Nov 01 ; 280(47) 39510 | DOI : https://doi.org/10.1074/jbc.M506131200
- F. Kerr
- et al