IMG-EN-AS-63877-01.jpg
Peptides

CSP-2, Competence-Stimulating Peptide-2 - 1 mg

$134.00
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  • Cat.Number : AS-63877
  • Availability :
    In production

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Genetic transformation in Streptococcus pneumoniae, Streptococcus mitis and Streptococcus oralis is regulated by secreted peptide pheromones named the competence-stimulating peptide (CSP). Different strains and species of these bacteria produce CSP with different primary sequence. They are termed pheromones CSP-1 (EMRLSKFFRDFILQRKK), CSP-2 (EMRISRIILDFLFLRKK), CSP-153 (DKRLPYFFKHLFSNRTK), CSP-612 (ESRLSRLLRDFIFQIKQ), CSP-676 (ERRIPDVIRSLLFQKRK), and CSP-12261 (EIRQTHNIFFNFFKRR).

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EMRISRIILDFLFLRKK
Sequence three letter code
  • H-Glu-Met-Arg-Ile-Ser-Arg-Ile-Ile-Leu-Asp-Phe-Leu-Phe-Leu-Arg-Lys-Lys-OH
Molecular Formula
  • C101H172N28O23S1
Molecular Mass/ Weight
  • 2178.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • streptococcus

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Citations

Designed reduction of Streptococcus pneumoniae pathogenicity via synthetic changes in virulence factor codon-pair bias.

J Infect Dis . 2011 Feb 21 ; 203(9) 1264 | DOI : 10.1093/infdis/jir010

  • J. Coleman

References

A predatory mechanism dramatically increases the efficiency of lateral gene transfer in Streptococcus pneumoniae and related commensal species

Mol Microbio . 2008 Jun 28 ; 69(1) 245 | DOI : https://doi.org/10.1111/j.1365-2958.2008.06288.x

  • O. Johnsborg
  • et al

Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon

Infection Immunity . 2001 May 01 ; 69(5) 3350 | DOI : 10.1128/IAI.69.5.3350-3358.2001

  • K. Francis
  • et al