IMG-EN-AS-61111-01.jpg
Peptides

Cyclo (-RGDfK) - 1 mg

$116.00
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  • Cat.Number : AS-61111
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In one study where this peptide was labeled with 125I, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence.

Specifications

Chemistry
Sequence one letter code
  • Cyclo(-RGDfK)
Sequence three letter code
  • Cyclo(-Arg-Gly-Asp-D-Phe-Lys)
CAS registry number
  • 161552-03-0
Molecular Formula
  • C27H41N9O7
Molecular Mass/ Weight
  • 603.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • synthetic

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Citations

RGD-functionalisation of PLLA nanofibers by surface coupling using plasma treatment: influence on stem cell differentiation.

J Mater Sci Mater Med . 2009 Nov 27 ; 21(4) 1363 | DOI : 10.1007/s10856-009-3947-2

  • J. Paletta

The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin.

Biomater . 2009 Oct 08 ; 31(4) 757 | DOI : 10.1016/j.biomaterials.2009.09.080

  • X. Xiong

Tumor-targeted HPMA copolymer-(RGDfK)-(CHX-A″-DTPA) conjugates show increased kidney accumulation.

J Controlled Release . 2008 Jul 18 ; 132(3) 193 | DOI : 10.1016/j.jconrel.2008.07.014

  • M. Borgman

References

Evaluation of a Radiolabelled Cyclic DTPA-RGD Analogue for Tumour Imaging and Radionuclide Therapy

Int J Cancer . 2000 Sep 13 ; 90(4) 186 | DOI : https://doi.org/10.1002/1097-0215(20000820)90:4<186::AID-IJC2>3.0.CO;2-P

  • PM. Van Hagen
  • et al