IMG-EN-AS-61183-5-01.jpg
Peptides

Cyclo (-RGDyK) - 5 mg

$249.00
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  • Cat.Number : AS-61183-5
  • Availability :
    In stock

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This is a cyclic derivative of RGD having a high affinity for αvβ3 integrin. It is considered the most prominent structure for the development of molecular imaging compounds in order to determine αvβ3 expression. It has been shown that both purified and membrane-bound αvβ3 intergrin binds to c(RGDyK) with high affinity.

Specifications

Chemistry
Sequence one letter code
  • Cyclo(-RGDyK)
Sequence three letter code
  • Cyclo(-Arg-Gly-Asp-D-Tyr-Lys)
CAS registry number
  • 217099-14-4
Molecular Formula
  • C27H41N9O8
Molecular Mass/ Weight
  • 619.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • synthetic

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Citations

Sequence elucidation of an unknown cyclic peptide of high doping potential by ETD and CID tandem mass spectrometry.

J Am Soc Mass Spectrom . 2011 Feb 18 ; 22(4) 718 | DOI : 10.1007/s13361-011-0080-5

  • F. Guan

Cyclic RGD peptide-labeled upconversion nanophosphors for tumor cell-targeted imaging.

Biochem Biophys Res Commun . 2009 Feb 08 ; 381(1) 54 | DOI : 10.1016/j.bbrc.2009.02.004

  • T. Zako

References

Biochemical characterization of the binding of cyclic RGDyK to hepatic stellate cells

Biochemical Pharmacology . 2010 Jul 01 ; 80(1) 136 | DOI : https://doi.org/10.1016/j.bcp.2010.03.015

  • X-W. Huang
  • et al

MicroPET and Autoradiographic Imaging of Breast Cancer αv-Integrin Expression Using 18F- and 64Cu-Labeled RGD Peptide

Bioconjug Chem . 2003 Dec 30 ; 15(1) 41 | DOI : https://doi.org/10.1021/bc0300403

  • X. Chen
  • et al