Peptides

Cytochrome C (MCC), Moth (88-103) - 1 mg

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  • Cat.Number : AS-60204-1
  • Availability :
    In stock

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This peptide is derived from the carboxyl terminus of moth MCC (88-103) and pigeon cytochrome c plays a major role in T-cell selection. MCC (88-103) can induce positive selection of TCR transgenic thymocytes.

Specifications

Chemistry
Sequence one letter code
  • ANERADLIAYLKQATK
Sequence three letter code
  • H-Ala-Asn-Glu-Arg-Ala-Asp-Leu-Ile-Ala-Tyr-Leu-Lys-Gln-Ala-Thr-Lys-OH
Molecular Formula
  • C79H133N23O25
Molecular Mass/ Weight
  • 1805.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • moth

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Citations

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding.

Nature Immunol . 2009 Mar 01 ; 10(4) 372 | DOI : 10.1038/ni.1704.

  • N. Fazilleau

IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition.

J Immunol . 2004 May 15 ; 172(10) 6136 | DOI : 10.4049/​jimmunol.172.10.6136.

  • DK. Sojka

Clonal selection of Helper T Cells is determined by an affinity threshold with no further skewing of TCR binding properties.

Immunity . 2004 Nov 01 ; 21(5) 669 | DOI : 10.1016/j.immuni.2004.09.008

  • L. Malherbe

References

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

Proc. Natl. Acad. Sci. USA . 1998 Mar 31 ; 95(7) 3804 | DOI : https://doi.org/10.1073/pnas.95.7.3804

  • R. Wang
  • et al

Single-Cell Analyses Reveal Two Defects in Peptide-Specific Activation of Naive T Cells from Aged Mice

J. Immunol. . 2001 Mar 01 ; 166 3151 | DOI : https://doi.org/10.4049/jimmunol.166.5.3151

  • G. Garcia
  • R. Miller