DNA-PK Substrate - 5 mg
- Cat.Number : AS-60210-5
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A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activity
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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References
Autoantibodies to DNA-dependent protein kinase. Probes for the catalytic subunit.
J Clin Invest . 1996 Mar 15 ; 97(6) 1417 | DOI : https://doi.org/10.1172/JCI118562.
- A. Suwa
- et al
Biochemical evidence for Ku‐independent backup pathways of NHEJ
Nucleic Acids Res . 2003 Sep 15 ; 31(18) 5377 | DOI : https://doi.org/10.1093/nar/gkg728
- H. Wang
- et al
Synergistic Effects of Retinoic Acid and 8-Chloro-Adenosine 3′,5′-Cyclic Monophosphate on the Regulation of Retinoic Acid Receptor β and Apoptosis: Involvement of Mitochondria
Clinical Cancer Res . 1999 Jul 01 ; 5(7) 1892 | DOI : PubMed: 10430097
- RK. Srivastava
- et al
Selective inhibition of the DNA‐dependent protein kinase (DNA‐PK) by the radiosensitizing agent caffeine
Nucleic Acids Res . 2004 Mar 15 ; 32(6) 1967 | DOI : https://doi.org/10.1093/nar/gkh508
- W. Block
- et al