IMG-EN-AS-61641-01.jpg
Peptides

Elafin - 0.1 mg

$357.00
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  • Cat.Number : AS-61641
  • Availability :
    In stock

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This is a fragment of the elafin (elastase-specific inhibitor), an antiproteinase and antimicrobial (gram-positive and gram-negative respiratory pathogens) molecule that is expressed at epithelial sites. Elafin is a potent inhibitor of HNE and proteinase 3 produced in the skin, and in the airways , which is up-regulated in response to early inflammatory cytokines such as TNF and IL-1. Elafin, along with SLPI, also shares characteristics with antimicrobial defensin-like molecules in being a low molecular weight cationic peptide with the ability to eliminate pulmonary pathogens.

Specifications

Chemistry
Sequence one letter code
  • AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ (Disufide bonds between Cys16- Cys45, Cys23- Cys49, Cys32- Cys44, Cys38-Cys53)
Sequence three letter code
  • H-Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr-Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln-OH (Disufide bonds between Cys16- Cys45, Cys23- Cys49, Cys32- Cys44, Cys38-Cys53)
Molecular Mass/ Weight
  • 5999.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, chimpanzee

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Citations

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.

Arterioscler Thromb Vasc Biol . 2012 Nov 29 ; 33(2) 275 | DOI : 10.1161/​ATVBAHA.112.300474

  • CJ. Kuckleburg
  • PJ. Newman

References

Adenoviral Augmentation of Elafin Protects the Lung Against Acute Injury Mediated by Activated Neutrophils and Bacterial Infection

J Immunol . 2001 Aug 01 ; 167(3) 1778 | DOI : https://doi.org/10.4049/jimmunol.167.3.1778

  • AJ. Simpson
  • et al

Elafin in Human Endometrium: An Antiprotease and Antimicrobial Molecule Expressed during Menstruation

J Clin Endo Metab . 2003 Sep 01 ; 88(9) 4426 | DOI : https://doi.org/10.1210/jc.2003-030239

  • A. King
  • et al

Elafin is a potent inhibitor of proteinase 3

Biochem Biophys Res Commun . 1991 Jan 15 ; 174(1) 6 | DOI : https://doi.org/10.1016/0006-291X(91)90476-N

  • O. Wiedow
  • et al

Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung

Am J Respir Crit Care Med . 1996 Oct 01 ; 154(4) 1092 | DOI : https://doi.org/10.1164/ajrccm.154.4.8887613

  • G. Tremblay
  • et al

Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence.

J Biol Chem . 1990 Sep 05 ; 265(25) 14791 | DOI : https://doi.org/10.1016/S0021-9258(18)77182-2

  • O. Wiedow
  • et al