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Protein

EndoClear™ mouse recombinant a-Synuclein protein

$133.00
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  • Cat.Number : AS-56082-100
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    In stock
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Alpha-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.

*For more stringent applications, EndoClear™Plus offers the lowest endotoxin research grade.

alpha-synuclein protein available in the market.

The sequence (Accession # NP_001035916) corresponding to the full-length mouse a-synuclein protein plus an affinity tag was expressed in E. coli. The recombinant a-synuclein protein was purified from bacterial lysate using proprietary method, including tag cleavage. The resulting protein contains an additional Gly at the N-term of the a-synuclein sequence. The calculated molecular mass of the recombinant a-synuclein protein is ~14.4 kDa.

Specifications

Chemistry
UniProt number
  • O55042
Molecular Mass/ Weight
  • 14.41 kDa
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • none (lyophilized)
Purification Method
  • Purified
Purity
  • ≥90% by SDS-PAGE
Endotoxin content
  • < 0.1EU/ug protein
Storage & stability
Form
  • Lyophilized
Storage Buffer
  • The purified a-synuclein is supplied as lyophilized powder nearly salt free.
Storage Conditions
  • Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for long-term storage. Avoid repeated freeze-thaw cycles
Activity
Application
Biomarker Target
Specificity
  • Recombinant mouse a-synuclein
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • mouse

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References

Modulation of alpha-synuclein aggregation by dopamine analogs

PloS ONE . 2010 Feb 16 ; 5(2) e9234 | DOI : 10.1371/journal.pone.0009234

  • D. Latawiec
  • et al

Molecular determinants of the aggregation behavior of α- and β-synuclein

Protein Sci . 2008 May 01 ; 17(5) 887 | DOI : https://doi.org/10.1110/ps.073181508

  • RC. Rivers
  • et al

Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary

Cancer . 2000 May 01 ; 88(9) 2154 | DOI : https://doi.org/10.1002/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9

  • W. Bruening