Endothelin 1, human, HiLyte™ Fluor 488-labeled - 0.25 mg
- Cat.Number : AS-64817-025
- Manufacturer Ref. :
-
Availability :
In production
Alternative choices
This is a fluorescent (HiLyte™ Fluor 488)-labeled Endothelin 1 (ET-1) peptide, Abs/Em=503/528 nm. ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
Specifications
| Chemistry | |
| Sequence one letter code |
|
|---|---|
| Sequence three letter code |
|
| Molecular Mass/ Weight |
|
| Properties | |
| Absorbance (nm) |
|
| Emission (nm) |
|
| Modification | |
| Conjugation type |
|
| Modification Name | |
| Conjugation |
|
| Quantity & Purity | |
| Purity |
|
| Storage & stability | |
| Form |
|
| Storage Conditions |
|
| Activity | |
| Biomarker Target | |
| Detection Method | |
| Research Area | |
| Sub-category Research Area | |
| Usage |
|
| Source | |
| Source / Species |
|
You may also be interested in the following product(s)
Citations
Desensitization and internalization of endothelin receptor A: impact of G protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation.
J Biol Chem . 2013 Sep 24 ; 288(45) 32138 | DOI : 10.1074/jbc.M113.461566.
- F. Gärtner
References
A Novel Potent Vasoconstrictor Peptide Produced by Vascular Endothelial Cells
Nature . 1988 Mar 31 ; 332 411 | DOI : 10.1038/332411a0.
- M. Yanagisawa
- et al