Peptides

GAD65 (524-543) - 1 mg

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  • Cat.Number : AS-62757
  • Availability :
    In production

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This is amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). It is one of the first fragments of this islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. This peptide is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with p524–543 increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.

Specifications

Chemistry
Sequence one letter code
  • SRLSKVAPVIKARMMEYGTT
Sequence three letter code
  • H-Ser-Arg-Leu-Ser-Lys-Val-Ala-Pro-Val-Ile-Lys-Ala-Arg-Met-Met-Glu-Tyr-Gly-Thr-Thr-OH
Molecular Formula
  • C97H168N28O28S2
Molecular Mass/ Weight
  • 2238.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat

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References

A Peptide of Glutamic Acid Decarboxylase 65 Can Recruit and Expand a Diabetogenic T Cell Clone, BDC2.5, in the Pancreas

J Immunol . 2005 Sep 15 ; 175(6) 3621 | DOI : https://doi.org/10.4049/jimmunol.175.6.3621

  • Y. Dai
  • et al

Regulatory and Effector CD4 T Cells in Nonobese Diabetic Mice Recognize Overlapping Determinants on Glutamic Acid Decarboxylase and Use Distinct Vβ Genes

J Immunol . 2001 Mar 01 ; 166(5) 2982 | DOI : https://doi.org/10.4049/jimmunol.166.5.2982

  • A. Quinn
  • et al