GAD65 (524-543) - 1 mg
- Cat.Number : AS-62757
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This is amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). It is one of the first fragments of this islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. This peptide is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with p524–543 increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.
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References
A Peptide of Glutamic Acid Decarboxylase 65 Can Recruit and Expand a Diabetogenic T Cell Clone, BDC2.5, in the Pancreas
J Immunol . 2005 Sep 15 ; 175(6) 3621 | DOI : https://doi.org/10.4049/jimmunol.175.6.3621
- Y. Dai
- et al
Regulatory and Effector CD4 T Cells in Nonobese Diabetic Mice Recognize Overlapping Determinants on Glutamic Acid Decarboxylase and Use Distinct Vβ Genes
J Immunol . 2001 Mar 01 ; 166(5) 2982 | DOI : https://doi.org/10.4049/jimmunol.166.5.2982
- A. Quinn
- et al