Peptides

Glucagon (1-29), bovine, human, rat, porcine, Biotin-labeled

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  • Cat.Number : AS-60274-05
  • Availability :
    In production

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Size

Quantity

This is N-terminal biotin labeled Glucagon (1-29). Glucagon is a peptide hormone secreted from the pancreatic Islet of Langerhans alpha-cells, in response to low circulating blood glucose levels in order to restore normal glucose levels. It acts on hepatic enzymes that regulate glucose production and glycogen synthesis. Excessive amounts of circulating glucagon levels is implicated in the metabolic dysregulation of type 2 diabetes, since such conditions result in hyperglycaemia.

Specifications

Chemistry
Sequence one letter code
  • Biotin-HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Sequence three letter code
  • Biotin-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
Molecular Formula
  • C163H239N45O51S2
Molecular Mass/ Weight
  • 3709.3
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • bovine, human, rat, porcine

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Citations

A novel high-sensitivity electrochemiluminescence (ECL) sandwich immunoassay for the specific quantitative measurement of plasma glucagon.

Clin Biochem . 2012 Aug 04 ; 45(18) 1640 | DOI : 10.1016/j.clinbiochem.2012.07.111.

  • JH. Sloan

References

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

Mol Cell Endocrinol . 2013 Dec 05 ; 381(1-2) 26 | DOI : 10.1016/j.mce.2013.07.014

  • FP. O'Harte
  • et al