Peptides

Glucagon (1-29), bovine, human, rat, porcine

  • Cat.Number : AS-22456
  • Availability :
    In production

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Size

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Glucagon is a peptide hormone secreted from the pancreatic Islet of Langerhans alpha-cells, in response to low circulating blood glucose levels in order to restore normal glucose levels. It acts on hepatic enzymes that regulate glucose production and glycogen synthesis. Excessive amounts of circulating glucagon levels is implicated in the metabolic dysregulation of type 2 diabetes, since such conditions result in hyperglycaemia.

Specifications

Chemistry
Sequence one letter code
  • HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Sequence three letter code
  • H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
CAS registry number
  • 16941-32-5
Molecular Formula
  • C153H225N43O49S
Molecular Mass/ Weight
  • 3483
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • bovine, human, rat, porcine

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Citations

Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.

JBC . 2000 Sep 01 ; 275(35) 27274 | DOI : 10.1074/jbc.M003910200

  • SRJ. Hoare

References

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

Mol Cell Endocrinol . 2013 Dec 05 ; 381(1-2) 26 | DOI : 10.1016/j.mce.2013.07.014

  • FP. O'Harte
  • et al