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Peptides

Glutamate Receptor Endocytosis Inhibitor, GluR23Y - 1 mg

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  • Cat.Number : AS-62547
  • Availability :
    In production

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This GluR23Y peptide was used in ELISA cell-surface assay for the insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y prevented any insulin-induced reduction. The blockade of insulin action was observed when the GluR23Y peptide was delivered into neurons by fusing it to the membrane transduction domain of HIV-1.

Specifications

Chemistry
Sequence one letter code
  • YKEGYNVYG
Sequence three letter code
  • H-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH
Molecular Formula
  • C51H69N11O16
Molecular Mass/ Weight
  • 1092.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat

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References

Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD.

EMBO J . 2004 Feb 19 ; 23(5) 1040 | DOI : 10.1038/sj.emboj.7600126

  • G. Ahmadian
  • et al

α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Subtype Glutamate Receptor (AMPAR) Endocytosis Is Essential for N-Methyl-D-aspartate-induced Neuronal Apoptosis

J. Biol. Chem. . 2004 Oct 01 ; 279(40) 41267 | DOI : https://doi.org/10.1074/jbc.C400199200

  • D. Wang
  • et al