IMG-EN-AS-62150-01.jpg
Peptides

[Gly21]-beta-Amyloid (1-40), A21G, Flemish Mutation - 0.5 mg

$275.00
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  • Cat.Number : AS-62150
  • Availability :
    In stock

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Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. Amond them, the A21G Flemish mutation is unique as it shows a low tendency to aggregation, while deposits progressively appear in the vessel walls. In addition, the brain deposits are prefereably composed of A-beta 1-40 rather than A beta 1-42, in opposition to the other familial AD.


Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Gly-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
CAS registry number
  • 154362-03-5
Molecular Formula
  • C193H293N53O58S
Molecular Mass/ Weight
  • 4316.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Hemorrhage is uncommon in new Alzheimer family with Flemish amyloid precursor protein mutation

Neurol . 2004 Nov 09 ; 63(9) 1613 | DOI : https://doi.org/10.1212/01.WNL.0000142965.10778.C7

  • W. Brooks
  • et al

Impact of the Mutation A21G (Flemish Variant) on Alzheimer’s β-Amyloid Dimers by Molecular Dynamics Simulations

Biophys J . 2006 Nov 15 ; 91(10) 3829 | DOI : https://doi.org/10.1529/biophysj.106.090993

  • A. Huet
  • P. Derreumaux

Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein

J Biol Chem . 2001 Aug 01 ; 276(35) 32860 | DOI : https://doi.org/10.1074/jbc.M104135200

  • W. Van Nostrand
  • et al