Labeling-detection

H2-DCFDA [2',7'-Dichlorodihydrofluorescein diacetate] - 100 mg

$111.00
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  • Cat.Number : AS-85706
  • Availability :
    In production

Quantity

Cell-permeable substrate for fluorimetric detection of oxidases (including peroxidase); used as an indicator for reactive oxygen species (ROS) in cells

Specifications

Chemistry
CAS registry number
  • 2044-85-1
Molecular Formula
  • C24H14Cl2O7
Molecular Mass/ Weight
  • 487.3
Properties
Absorbance (nm)
  • 495
Emission (nm)
  • 529
Color
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Resuspension condition
  • DMSO
Storage Conditions
  • -20°C Protected from Light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Mercury abolishes neurotrophic factor–stimulated Jak-STAT signaling in nerve cells by oxidative stress.

Toxical Sci . 2006 Aug 08 ; 94(1) 129 | DOI : 10.1093/toxsci/kfl073

  • R. Monroe

Novel genetic tools reveal Cdk5's major role in golgi fragmentation in Alzheimer's Disease.

Mol Biol Cell . 2008 May 14 ; 19(7) 3052 | DOI : 10.1091/mbc.e07-11-1106

  • K-H. Sun

MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.

Dev Biol . 2010 Apr 07 ; 342(1) 96 | DOI : 10.1016/j.ydbio.2010.03.026

  • Y. Yang

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis.

PNAS. . 2012 Jul 02 ; 109(29) 11758 | DOI : 10.1073/pnas.1209592109

  • M. Geyfman

References

A Direct, Highly Sensitive Fluorometric Assay for a Microsomal Cytochrome P450-Mediated O-Demethylation Using a Novel Coumarin Analog as Substrate

Z Naturforsch [C] . 2000 Nov 01 ; 55(11-12) 915 | DOI : https://doi.org/10.1515/znc-2000-11-1212

  • R. Roser
  • H. Thomas

Coumarin Substrates for Cytochrome P450 2D6 Fluorescence Assays

Anal Biochem . 2001 May 15 ; 292(2) 280 | DOI : https://doi.org/10.1006/abio.2001.5098

  • K. Nakamura
  • et al

Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4)

Bioorg Med Chem Lett . 2003 Nov 03 ; 13(21) 3643 | DOI : https://doi.org/10.1016/j.bmcl.2003.08.027

  • A. Chougnet
  • et al

FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES

Drug Metab Dispos . 2004 Jul 01 ; 32(7) 699 | DOI : https://doi.org/10.1124/dmd.32.7.699

  • MT. Donato
  • et al

Fluorescent probes for cytochrome p450 structural characterization and inhibitor screening

J Am Chem Soc . 2002 Aug 10 ; 124(35) 10254 | DOI : https://doi.org/10.1021/ja0271678

  • AR. Dunn
  • et al

Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo

Food Chem Toxicol . 2001 Jun 01 ; 39(6) 541 | DOI : https://doi.org/10.1016/S0278-6915(00)00165-4

  • R. Thapliyal
  • GB. Maru

The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism

Arch Biochem Biophys . 2004 Apr 01 ; 424(1) 33 | DOI : https://doi.org/10.1016/j.abb.2003.12.040

  • J. Liu
  • et al

Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants

Biochem . 1998 Apr 22 ; 37(19) 6679 | DOI : https://doi.org/10.1021/bi9731450

  • Y. Kobayashi
  • et al