HIV-1 protease, recombinant - 5 µg
- Cat.Number : AS-72028-5
- Manufacturer Ref. :
-
Availability :
In stock
- Shipping conditions : Ice fees will apply
The 10~12 kDa aspartic protease of human immunodeficiency virus-1 (HIV-1), active only when it forms a homodimer, is required for the post-translational cleavage of the precursor polyproteins, Gag, Gag-Pol, Pol, and Nef. Since the cleavages of precursors are essential for the maturation of HIV infectious particles, this protease is one of the key targets for developing anti-AIDS drugs
The recombinant HIV-1 protease (wild type, NCBI accession: NC_001802) contains the 99 amino acid sequence as reported by Schneider, et al. (Cell 54, 363;1988) with 6x His-tag at its C-terminal. HIV-1 protease activity can be measured using enzymatic assay with FRET substrates.
Specifications
Chemistry | |
Molecular Mass/ Weight |
|
---|---|
Modification | |
Conjugation |
|
Quantity & Purity | |
Concentration |
|
Purity |
|
Storage & stability | |
Form |
|
Storage Conditions |
|
Activity | |
Application | |
Biomarker Target | |
Unit definition |
|
Specificity |
|
Research Area | |
Sub-category Research Area | |
Usage |
|
Source | |
Host | |
Source / Species |
|
Downloads
You may also be interested in the following product(s)



References
Enzymatic activity of a synthetic 99 residue protein corresponding to the putative HIV-1 protease
Cell . 1988 Jul 29 ; 54(3) 363 | DOI : https://doi.org/10.1016/0092-8674(88)90199-7
- J. Schneider
- SBH. Kent
Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A
PNAS USA . 1988 Sep 01 ; 85(18) 6612 | DOI : https://doi.org/10.1073/pnas.85.18.6612
- S. Seelmeier
- et al