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Peptides

Indolicidin - 1 mg

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  • Cat.Number : AS-60999
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Indolicidin, a member of the cathelicidin protein family, is a 13-residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. Indolicidin is microbicidal in-vitro against gram-positive and gram-negative bacteria, fungi, protozoa, and human immunodeficiency virus (HIV-1).

Specifications

Chemistry
Sequence one letter code
  • ILPWKWPWWPWRR-NH2
Sequence three letter code
  • H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2
CAS registry number
  • 140896-21-5
Molecular Formula
  • C100H132N26O13
Molecular Mass/ Weight
  • 1906.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Bovine

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Citations

Combination effects of antimicrobial peptides

Antimicrob Agents Chemother . 2016 Jan 04 ; 60(3) 1717 | DOI : 10.1128/AAC02434-15.

  • G. Yu

Acyl carrier protein is a bacterial cytoplasmic target of cationic antimicrobial peptide LL-37

Biochem J . 2015 Jul 17 ; 470(2) 243 | DOI : 10.1042/BJ20150432.

  • MC. Chung

Screening Antimicrobial Peptides In Vitro for Use in Developing Transgenic Citrus Resistant to Huanglongbing and Citrus Canker

Ameri Soci Horticul Sci . 2013 Mar 01 ; 138(2) 142 | DOI : https://doi.org/10.21273/JASHS.138.2.142

  • E. Stover

Antimicrobial peptide inhibition of Porphyromonas gingivalis 381-induced hemagglutination is improved with a synthetic decapeptide.

Peptides . 2009 Aug 08 ; 30(12) 2161 | DOI : 10.1016/j.peptides.2009.07.027.

  • DR. Dixon

References

Formation and Characterization of a Single Trp-Trp Cross-link in Indolicidin That Confers Protease Stability without Altering Antimicrobial Activity

J Biol Chem . 2000 Apr 01 ; 275(16) 12017 | DOI : https://doi.org/10.1074/jbc.275.16.12017

  • K. Ösapay
  • et al

Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils

J Leukocyte Biol . 1998 Jan 01 ; 63(1) 94 | DOI : https://doi.org/10.1002/jlb.63.1.94

  • W. Robinson
  • et al

Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity

Biochim Biophys Acta . 1995 Jul 26 ; 1237(2) 109 | DOI : https://doi.org/10.1016/0005-2736(95)00087-J

  • I. Ahmad
  • et al

Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides

Infect Immun . 1994 Dec 01 ; 62(12) 5397 | DOI : https://doi.org/10.1128/iai.62.12.5397-5403.1994

  • SB. Aley
  • et al