Peptides

Influenza NP (311-325) - 1 mg

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  • Cat.Number : AS-62420
  • Availability :
    In stock

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This peptide is amino acids 311 to 325 fragment of the influenza virus nucleoprotein (NP). This bona fide MHC class II restricted epitope from influenza virus was used to study the host immunoresponse during the infection. This peptide elicits the strongest gamma interferon (IFN-gamma) production in the intracellular cytokine assays. It does not stimulate CD8 T-cells in mice.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • QVYSLIRPNENPAHK
Sequence three letter code
  • H-Gln-Val-Tyr-Ser-Leu-Ile-Arg-Pro-Asn-Glu-Asn-Pro-Ala-His-Lys-OH
Molecular Formula
  • C78H124N24O23
Molecular Mass/ Weight
  • 1766.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Influenza

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References

Uneven distribution of MHC class II epitopes within the influenza virus

Vaccine . 2006 Jan 23 ; 24(4) 457 | DOI : https://doi.org/10.1016/j.vaccine.2005.07.096

  • S. Crowe
  • et al