IMG-EN-AS-62049-01.jpg
Peptides

Integrin-Binding Site, GRGDNP - 1 mg

$81.00
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  • Cat.Number : AS-62049
  • Availability :
    In stock

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This RGD-containing sequence is integrin-binding site. RGD peptides are found in both extracellular matrix (ECM) (e.g., collagen, osteopontin, fibronectin, and vitronectin) and non-ECM proteins (e.g., disintegrins). RGD-containing peptides are recognized by several integrins. This peptide targets both alphavbeta3 and alpha5beta1 integrins. Interaction of the RGDN sequence with endothelial alpha5beta1 integrin causes endothelin-mediated arteriolar vasoconstriction. This peptide influences the IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) activation. It also controls the cardiac contractile function.

Specifications

Chemistry
Sequence one letter code
  • GRGDNP
Sequence three letter code
  • H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS registry number
  • 114681-65-1
Molecular Formula
  • C23H38N10O10
Molecular Mass/ Weight
  • 614.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • synthetic

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References

Arginine–glycine–aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via α5β1 integrin

J Physiol . 2005 Apr 06 ; 564(2) 603 | DOI : https://doi.org/10.1113/jphysiol.2005.083238

  • V. Sarin
  • et al

Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch

Am J Physiol Cell Physiol . 2005 May 01 ; 288(5) C1912 | DOI : 10.1152/ajpcell.00314.2004

  • A. Sasamoto
  • et al

RGDN peptide interaction with endothelial alpha5beta1 integrin causes sustained endothelin-dependent vasoconstriction of rat skeletal muscle arterioles

J. Clin. Invest. . 1997 Sep 15 ; 100(6) 1647 | DOI : 10.1172/JCI119689

  • J. Mogford
  • et al