IV9 (476-484), HIV-1 RT Epitope - 1 mg
- Cat.Number : AS-61524
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This is a reverse transcriptase (RT) epitope (Pol residues 476-484). Within HIV-1 RT the peptide appears to be the dominant HLA A*0201-restricted epitope. Was used to investigate possible mechanisms behind HIV-1 escape from CTL. IV9 is the actual epitope processed and presented in HIV-1-infected cell lines.
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References
Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses
J Immunol . 2003 Nov 15 ; 171(10) 5372 | DOI : https://doi.org/10.4049/jimmunol.171.10.5372
- B. Jamieson
- et al
IFN-γ Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase
J Immunol . 1999 Jun 15 ; 162(12) 7075
- A. Sewell
- et al
Lack of strong immune selection pressure by the immunodominant, HLA-A 0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.
J Clin Invest . 1998 Jun 01 ; 101(11) 2559 | DOI : 10.1172/JCI2405
- C. Brander
- et al
Patterns of Immunodominance in HIV-1–specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-identical Siblings with HLA-A 0201 Are Influenced by Epitope Mutation
JEM . 1997 Apr 21 ; 185(8) 1423 | DOI : https://doi.org/10.1084/jem.185.8.1423
- P. Goulder
- et al