IMG-EN-AS-61298-01.jpg
Peptides

JAG-1 (188-204), Jagged-1 (188-204), Notch Ligand, DSL Peptide - 1 mg

$213.00
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  • Cat.Number : AS-61298
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This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspiciously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-kB activation.

Specifications

Chemistry
Sequence one letter code
  • CDDYYYGFGCNKFCRPR
Sequence three letter code
  • H-Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg-OH
Molecular Formula
  • C93H127N25O26S3
Molecular Mass/ Weight
  • 2107.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion

Nat Commun. . 2016 Jan 19 ; 7 10380 | DOI : 10.1038/ncomms10380

  • Y. Yamamoto

Notch signaling activation is critical to the development of neuropathic pain

BMC Anesthesiol . 2015 Mar 28 ; 15 41 | DOI : 10.1186/s12871-015-0021-0

  • K. Xie

Cloning and Variation of Ground State Intestinal Stem Cells

Nature . 2015 Jun 03 ; 522 173 | DOI : 10.1038/nature14484

  • X. Wang

Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells.

Am J Physiol Cell Physiol . 2014 Feb 26 ; 306 C871 | DOI : 10.1152/ajpcell.00221.2013

  • H. Yamamura

Tbx1 regulates brain vascularization

Hum Mol Genet . 2013 Aug 14 ; 23(1) 78 | DOI : 10.1093/hmg/ddt400

  • S. Cioff

Genetic reconstitution of tumorigenesis in primary intestinal cells

Proc Natl Acad Sci U S A . 2013 Jun 17 ; 110(27) 11127 | DOI : 10.1073/pnas.1221926110

  • K. Onuma

Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay

Gastroenterology. . 2013 May 02 ; 145(2) 383 | DOI : 10.1053/j.gastro.2013.04.050

  • F. Wang

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Development. . 2011 Dec 21 ; 139(3) 488 | DOI : 10.1242/dev.070763

  • KL. VanDussen

Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation

Am J Physiol Gastrointest Liver Physiol. . 2012 Feb 23 ; 302(10) G1111 | DOI : 10.1152/ajpgi.00519.2011

  • L. Van Landeghem

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

Am J Physiol Gastrointest Liver Physiol. . 2012 Feb 16 ; 302(9) G914 | DOI : 10.1152/ajpgi.00402.2011

  • RG. Fox

Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture

Am J Physiol Gastrointest Liver Physiol. . 2011 Oct 13 ; 302(1) G10 | DOI : 10.1152/ajpgi.00277.2011

  • S. Ramalingam

Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: Implications for HIV-associated neurological disorders

J Neurosci. . 2011 Aug 11 ; 31(35) 12449 | DOI : 10.1523/JNEUROSCI.2330-11.2011

  • H. Yao

Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro

Am J Physiol Gastrointest Liver Physiol. . 2010 Feb 25 ; 298(5) G590 | DOI : 10.1152/ajpgi.00470.2009

  • AD. Gracz

Expression and role of Notch signalling in the regeneration of rat tracheal epithelium

Cell Prolif. . 2009 Feb 01 ; 42(1) 15 | DOI : 10.1111/j.1365-2184.2008.00569.x

  • XB. Ma

Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis.

FASEB Journal . 2005 Mar 17 ; 19(8) 1027 | DOI : 10.1096/fj.04-3172fje

  • RCA. Sainson

References

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ

Cell Death Different . 2002 Jul 16 ; 9(8) 842 | DOI : 10.1038/sj.cdd.4401036

  • B. Nickoloff
  • et al