[Leu27]-Melan-A, MART-1 (26-35) - 1 mg
- Cat.Number : AS-61013
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This Melan-A (26-35) analog, Leu substituted for Ala at position 27, shows better HLA-A*0201 binding properties as well as better immunogenicity and antigenicity than the natural Melan-A (26-35).
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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References
Assessment of immunogenicity of human Melan-A peptide analogues in HLA-A*0201/Kb transgenic mice
J Immunol . 1999 Mar 15 ; 162(6) 3566
- Y. Men
- et al
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
PNAS USA . 1994 Apr 26 ; 91(9) 3515 | DOI : https://doi.org/10.1073/pnas.91.9.3515
- Y. Kawakami
- et al
Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes
Cancer Res . 2001 Jul 01 ; 61(13) 5153
- C. Pinilla
- et al