Peptides

[Lys0]-Bradykinin (Kallidin) - 5 mg

  • Cat.Number : AS-22853
  • Availability :
    In stock

Quantity

Bradykinins (BK) and related kinins are potent inflammatory mediators produced during acute and chronic inflammation. The two main ‘kinins’ in mammals are the nonapeptide bradykinin, BK (1-9) and the decapeptide kallidin (KD), [Lys0]-BK(1-10). Their biological actions are mediated by two distinct receptors, termed B1 and B2. BK and [Lys0]-BK are peptides which are released at high nanomolar concentrations into the tear-film of ocular allergic patients.

Specifications

Chemistry
Sequence one letter code
  • KRPPGFSPFR
Sequence three letter code
  • H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
CAS registry number
  • 342-10-9
Molecular Formula
  • C56H85N17O12
Molecular Mass/ Weight
  • 1188.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Nonpeptide antagonists for kinin receptors

Regul Pept . 1999 Mar 17 ; 80(1) 13 | DOI : https://doi.org/10.1016/S0167-0115(99)00003-8

  • M. Altamura
  • et al

B1 kinin receptor activity in pigs is associated with pre-existing infection

Immunopharmacol . 1998 Jul 01 ; 40(1) 49 | DOI : https://doi.org/10.1016/S0162-3109(98)00035-6

  • M. Siebeck
  • et al

The expression of functionally‐coupled B2‐bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists

Br J Pharmacol . 2009 Feb 13 ; 121(4) 649 | DOI : 10.1038/sj.bjp.0701168

  • T. Wiernas
  • et al