IMG-EN-AS-62147-01.jpg
Peptides

[Lys22]-beta-Amyloid (1-40), Italian Mutation - 0.5 mg

$275.00
Check your price
  • Cat.Number : AS-62147
  • Availability :
    In stock

Alternative choices

Quantity

Add to wishlist Bulk Quote

Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. Among them, the Italian mutation (E22K) leads to beta-amyloid peptides which aggregate more rapidly and exhibit potent neurotoxicity compared to wild-type beta-amyloid 1-40. The formation of a salt bridge between Lys-22 and Asp-23 in the minor conformer might explain why E22K-beta-amyloid 1-40 is more pathogenic than its wild-type conterpart.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVV
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
CAS registry number
  • 302905-01-7
Molecular Formula
  • C195H300N54O56S
Molecular Mass/ Weight
  • 4329.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

Downloads

You may also be interested in the following product(s)

IMG-EN-AS-72215-01.jpg

AggreSure ß-Amyloid (1-40), human - 0.25 mg

Cat.Number : AS-72215
$330.00 Excl. Tax
IMG-EN-AS-20276-01.jpg

Beta-Amyloid (1-42)

Cat.Number : AS-20276
$341.00 Excl. Tax
IMG-EN-AS-55553-01.jpg

SensoLyte® Anti-Mouse/Rat ß-Amyloid (1-40) Quantitative ELISA Kit Colorimetric - 1 kit

Cat.Number : AS-55553
$594.00 Excl. Tax

References

Verification of the turn at positions 22 and 23 of the β-amyloid fibrils with Italian mutation using solid-state NMR

Bioorg. Med. Chem. . 2005 Dec 15 ; 13(24) 6803 | DOI : https://doi.org/10.1016/j.bmc.2005.07.071

  • Y. Masuda
  • et al