Peptides

MBP, MAPK Substrate [APRTPGGRR] - 5 mg

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  • Cat.Number : AS-27168
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The sequence APRTPGGRR contains a native sequence derived from bovine myelin basic protein amino acids 95-98 (PRTP). The rest of the sequence is not derived from a native sequence, but is a synthetic construct. This substrate is specific for MAP kinases: p44MAPK [extracellular signal-regulated kinase 1 (ERK1)] and p42MAPK (ERK2). It contains the consensus sequence Pro-X-(Ser/Thr)-Pro that is recognized by MAP kinase. This peptide is the most efficient substrate for phosphorylation reaction by ERK. The substrate is phosphorylated by kinases on threonine 97 and can also be phosphorylated by MAPK p38.

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References

A New Peptide Conjugate as a Highly Specific Substrate for MAP Kinase

J Biochem . 1997 Jul 01 ; 122(1) 168

  • I. Kameshita
  • et al

Activation and Phosphorylation on Thr-160 of Nuclear-Targeted CDK2 Is ERK Dependent

Ann NY Acad Sci . 2006 Jan 24 ; 973(1) 265 | DOI : https://doi.org/10.1111/j.1749-6632.2002.tb04646.x

  • NH. Lents
  • et al

Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle.

J Physiol . 1996 Sep 01 ; 495(3) 597 | DOI : https://doi.org/10.1113/jphysiol.1996.sp021619

  • W. Gerthoffer
  • et al

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

JBC . 1991 Aug 15 ; 266(23) 15180 | DOI : https://doi.org/10.1016/S0021-9258(18)98601-1

  • I. Clark-Lewis
  • et al

Determination of protein phosphorylation by extracellular signal-regulated kinase using capillary electrophoresis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry

J Chromatogr A . 2002 Nov 08 ; 976(1-2) 79 | DOI : https://doi.org/10.1016/S0021-9673(02)01148-2

  • H. Nam
  • et al

MAP kinase 1/2 (Erk 1/2) and serine/threonine specific protein kinase Akt/PKB expression and activity in the human corpus cavernosum

IJIR . 2002 Aug 05 ; 14 217 | DOI : https://doi.org/10.1038/sj.ijir.3900856

  • F. Sommer
  • et al

Modulation of Rat Rotational Behavior by Direct Gene Transfer of Constitutively Active Protein Kinase C into Nigrostriatal Neurons

J Neurosci . 1998 Jun 01 ; 18(11) 4119 | DOI : https://doi.org/10.1523/JNEUROSCI.18-11-04119.1998

  • S. Song
  • et al