MBP, MAPK Substrate [APRTPGGRR], Biotinylated - 1 mg
- Cat.Number : AS-60747
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This is an N-terminally biotinylated peptide. The sequence APRTPGGRR contains a native sequence derived from bovine myelin basic protein amino acids 95-98 (PRTP). The rest of the sequence is not derived from a native sequence, but is a synthetic construct. This substrate is specific for MAP kinases: p44MAPK [extracellular signal-regulated kinase 1 (ERK1)] and p42MAPK (ERK2). It contains the consensus sequence Pro-X-(Ser/Thr)-Pro that is recognized by MAP kinase. This peptide is the most efficient substrate for phosphorylation reaction by ERK. The substrate is phosphorylated by kinases on threonine 97 and can also be phosphorylated by MAPK p38.
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References
A New Peptide Conjugate as a Highly Specific Substrate for MAP Kinase
J Biochem (Tokyo) . 1997 Jul 01 ; 122(1) 168 | DOI : 10.1093/oxfordjournals.jbchem.a021723
- I. Kameshita
- et al
Activation and Phosphorylation on Thr-160 of Nuclear-Targeted CDK2 Is ERK Dependent
Ann N. Y. Acad Sci . 2002 Nov 01 ; 973(1) 265 | DOI : https://doi.org/10.1111/j.1749-6632.2002.tb04646.x
- NH. Lents
- et al
MAP kinase 1/2 (Erk 1/2) and serine/threonine specific protein kinase Akt/PKB expression and activity in the human corpus cavernosum
Int J Impot Res . 2002 Aug 05 ; 14(4) 217 | DOI : https://doi.org/10.1038/sj.ijir.3900856
- F. Sommer
- et al