MOG (35-55), mouse, rat
- Cat.Number : AS-60130-1
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Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system. MOG (35-55) is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to MOG (35-55) has been observed in multiple sclerosis (MS) patients and MOG (35-55)-induced experimental autoimmune encephalomyelitis (EAE) C57/BL6 mice and Lewis rats. Every lot of MOG (35-55) peptide is tested and proven to induce EAE.
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Citations
Zinc transporter 3 (ZnT3) gene deletion reduces spinal cord white matter damage and motor deficits in a murine MOG-induced multiple sclerosis model
Neurobiol Dise . 2016 Oct 01 ; 94 205 | DOI : https://doi.org/10.1016/j.nbd.2016.06.018
- BY. Choi
2′-5′ oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model
Neurosci Lett . 2016 Aug 15 ; 628 78 | DOI : https://doi.org/10.1016/j.neulet.2016.06.026
- B. Choi
CCRL2 regulates M1/M2 polarization during EAE recovery phase
J Leukoc Biol . 2016 Jan 17 ; 99(6) 1027 | DOI : 10.1189/jlb.3MA0915-444RR
- C. Mazzon
Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis
Am J Transl Res . 2016 Feb 15 ; 8(2) 1016 | DOI : PMC4846944
- RA. Chandraratna
Altered Expression of Specific Transcription Factors of Th17 (RORγt, RORα) and Treg Lymphocytes (FOXP3) by Peripheral Blood Mononuclear Cells from Patients with Multiple Sclerosis
J Mol Neurosci. . 2016 Jul 02 ; 60(1) 94 | DOI : 10.1007/s12031-016-0789-5
- Z. Etesam
Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis
Stem Cell Res Ther . 2016 Jan 04 ; 7 1 | DOI : 10.1186/s13287-015-0253-4
- O. Trubiani
Transmembrane TNF–TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression
J Immunol . 2015 Sep 15 ; 195(6) 2633 | DOI : https://doi.org/10.4049/jimmunol.1500286
- PG. Miller
NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice
Intl immunol . 2015 Jan 08 ; 27(5) 237 | DOI : https://doi.org/10.1093/intimm/dxu147
- A. Maddell
Central Canal Ependymal Cells Proliferate Extensively in Response to Traumatic Spinal Cord Injury but Not Demyelinating Lesions
PLoS One . 2009 Dec 09 ; 9(1) e85916 | DOI : 10.1371/journal.pone.0085916
- S. Lacroix
Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis
J Neurochem . 2014 Jan 28 ; 129(4) 696 | DOI : https://doi.org/10.1111/jnc.12664
- A. Boullerne
Dominant Effects of the Diet on the Microbiome and the Local and Systemic Immune Response in Mice
PLoS One . 2014 Jan 29 ; 9(1) e86366 | DOI : 10.1371/journal.pone.0086366
- JH. Ooi
Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases
J Immunol . 2014 Jul 21 ; 204(2) 2438 | DOI : 10.4049/jimmunol.1400401
- B. Aubé
CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis
J Neuroimmunol . 2014 Sep 15 ; 274(1-2) 230 | DOI : https://doi.org/10.1016/j.jneuroim.2014.06.015
- JM. Cantor
Sex‐specific control of central nervous system autoimmunity by p38 mitogen‐activated protein kinase signaling in myeloid cells
Ann Neurol . 2013 Sep 11 ; 75(1) 50 | DOI : 10.1002/ana.24020
- DN. Krementsov
The adaptor TRAF5 limits the differentiation of inflammatory CD4+ T cells by antagonizing signaling via the receptor for IL-6
Nat Immunol . 2014 Mar 30 ; 15(5) 449 | DOI : 10.1038/ni.2863
- H. Nagashima
Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling
Brain Behav Immun . 2014 Aug 27 ; 40 61 | DOI : https://doi.org/10.1016/j.bbi.2014.02.003
- S. Ouyang
Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway
J Immunol . 2012 Sep 19 ; 189(9) 4417 | DOI : 10.4049/jimmunol.1200919
- YG. Zhao
Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis
Brain . 2011 Feb 04 ; 134(Pt 3) 665 | DOI : 10.1093/brain/awq362
- P. Polak
GH, but not GHRH, plays a role in the development of experimental autoimmune encephalomyelitis
Endocrinology . 2011 Aug 16 ; 152(10) 3803 | DOI : 10.1210/en.2011-1317
- R. Shohreh
The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice
J Neuroimmunol . 2010 Sep 24 ; 229(1-2) 192 | DOI : 10.1016/j.jneuroim.2010.08.022
- E. Aizman
Increasing CNS noradrenaline reduces EAE severity
J Neuroimmune Pharmacol . 2009 Dec 04 ; 5(2) 252 | DOI : 10.1007/s11481-009-9182-2
- MV. Simonini
Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins.
ASN Neuro . 2010 Jan 15 ; 2(1) e00025 | DOI : 10.1042/AN20090033
- MV. Simonini
Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs
Mol Ther . 2010 Jan 12 ; 18(5) 1035 | DOI : 10.1038/mt.2009.293
- MG. Toscano
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels
Biochem Biophys Res Commun . 2009 May 09 ; 385(1) 49 | DOI : 10.1016/j.bbrc.2009.05.020
- T. Kawasaki
Augmenting DAF levels in vivo ameliorates experimental autoimmune encephalomyelitis
Mol Immunol . 2009 Aug 05 ; 46(15) 2885 | DOI : 10.1016/j.molimm.2009.07.003
- Q. Li
The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis
Am J Pathol . 2009 Jul 16 ; 175(2) 661 | DOI : 10.2353/ajpath.2009.081093
- Q. Li
The type 1 IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
J Clin Invest . 2008 May 01 ; 118(5) 1680 | DOI : 10.1172/JCI33342
- B. Guo
P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis
J Neuroinflammation . 2008 Aug 08 ; 5 33 | DOI : 10.1186/1742-2094-5-33
- AJ. Sharp
Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction
Exp Neurol. . 2015 Feb 20 ; 266 74 | DOI : 10.1016/j.expneurol.2015.02.018
- DS. Barkauskas
Differential Roles of IL-2 Signaling in Developing versus Mature Tregs
Cell Rep . 2018 Oct 30 ; 25(5) 1204 | DOI : https://doi.org/10.1016/j.celrep.2018.10.002
- M. Fan
Contribution of LTi and TH17 cells to B cell aggregate formation in the central nervous system in a mouse model of multiple sclerosis
J Neuroinflammat . 2019 May 28 ; 16 111 | DOI : https://doi.org/10.1186/s12974-019-1500-x
- V Schropp
- et al
References
Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency
J Neuroimmunol . 2007 Oct 26 ; 192(1-2) 124 | DOI : 10.1016/j.jneuroim.2007.09.024
- RF. Frausto
Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis
J Neuroimmunol . 2003 Feb 01 ; 135(1-2) 117 | DOI : https://doi.org/10.1016/S0165-5728(02)00434-4
- A. Kennel De March
- et al
IgG Subclass Switching Is Associated with the Severity of Experimental Autoimmune Encephalomyelitis Induced with Myelin Oligodendrocyte Glycoprotein Peptide in NOD Mice
Cellular Immunol . 1999 Feb 01 ; 191(2) 97 | DOI : https://doi.org/10.1006/cimm.1998.1414
- M. Ichikawa
- et al
Induction of a Multiple Sclerosis-Like Disease in Mice with an Immunodominant Epitope of Myelin Oligodendrocyte Glycoprotein
Autoimmunity . 1997 Oct 29 ; 28(2) 109 | DOI : https://doi.org/10.3109/08916939809003872
- A. Slavin
- et al