MOTS-c - 1 mg
- Cat.Number : AS-65587
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Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2 Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2 All of these peptides are released into cytosol from mitochondria and associate with increased longevity and cell viability, reduced apoptosis, and other beneficial functions. 1-3 MOTS-c was found to reduce insulin resistance, decrease obesity, and promote homeostasis. 3
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References
The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity
Sci Reports . 2017 Aug 10 ; 7(7802) 1 | DOI : https://doi.org/10.1038/s41598-017-08372-5
- A.K. Okada
- et al
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
Cell Met . 2015 Mar 03 ; 21(3) 443 | DOI : https://doi.org/10.1016/j.cmet.2015.02.009
- C. Lee
- et al
Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers
AGING . 2016 Apr 10 ; 8(4) 796 | DOI : 10.18632/aging.100943
- L.J. Cobb
- et al