IMG-EN-AS-61451-01.jpg
Peptides

MUC1, tandem repeat fragment - 1 mg

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  • Cat.Number : AS-61451
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This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide. It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies.

Specifications

Chemistry
Sequence one letter code
  • PDTRPAPGSTAPPAHGVTSA
Sequence three letter code
  • Pro-Asp-Thr-Arg-Pro-Ala-Pro-Gly-Ser-Thr-Ala-Pro-Pro-Ala-His-Gly-Val-Thr-Ser-Ala
Molecular Formula
  • C80H127N25O28
Molecular Mass/ Weight
  • 1887.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Ex Vivo Expansion of CD8+CD56+ and CD8+CD56− Natural Killer T Cells Specific for MUC1 Mucin

Cancer Res . 2004 Feb 01 ; 64(3) 1171 | DOI : https://doi.org/10.1158/0008-5472.CAN-3254-2

  • H. Wajchman
  • et al

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

Blood . 1999 Jun 15 ; 93(12) 4309 | DOI : https://doi.org/10.1182/blood.V93.12.4309

  • P. Brossart
  • et al