Neurotensin (8-13) - 5 mg

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  • Cat.Number : AS-22964
  • Availability :
    In stock

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Neurotensin is a 13 amino acid neuropeptide first isolated from bovine hypothalamus. It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract, where it induces smooth muscle contraction. In the CNS, neurotensin has a dual function of neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It also shows potent hypothermic and analgesic effects in the brain. Neurotensin has been implicated in the pathophysiology of schizophrenia, Huntington, and Parkinson diseases.
The intrastriatal perfusion with Neurotensin (1-13) [NT(1-13)] and its active fragment NT(8-13) on striatopallidal GABA leads to the increased striatal and pallidal GABA release, and this effect is antagonized by intrastriatal perfusion with the NT receptor antagonist. In other experiments, NT, NT (8-13) and [D-Tyr(11)] NT are applied into the ventral tegmental area on extracellular dopamine in the prefrontal cortex and nucleus accumbens of rats. In the prefrontal cortex, neurotensin (8-13) is as potent as neurotensin but ineffective in [D-Tyr(11)]neurotensin. In the caudal nucleus accumbens, neurotensin (8-13) and neurotensin appears more potent than [D-Tyr(11)]neurotensin. In contrast, in the rostral nucleus accumbens, neurotensin(8-13) is less potent than [D-Tyr(11)]neurotensin and neurotensin.


Sequence one letter code
Sequence three letter code
  • H-Arg-Arg-Pro-Tyr-Ile-Leu-OH
CAS registry number
  • 60482-95-3
Molecular Formula
  • C38H64N12O8
Molecular Mass/ Weight
  • 817
  • Unconjugated
Quantity & Purity
  • Peak Area by HPLC ≥95%
Storage & stability
  • Lyophilized
Storage Conditions
  • - 20 °C
Biomarker Target
Research Area
Sub-category Research Area
  • Research use
Source / Species
  • human, rat, bovine, mouse

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Selection and characterization of DARPins specific for the neurotensin receptor 1.

Protein Eng Des Sel . 2009 Apr 22 ; 22(6) 357 | DOI : 10.1093/protein/gzp011

  • P. Milovnik


Comparative effects of neurotensin, neurotensin(8-13) and [D-Tyr11]neurotensin applied into the ventral tegmental area on extracellular dopamine in the rat prefrontal cortex and nucleus accumbens

Neurosci . 2000 Jun 01 ; 98(3) 485 | DOI :

  • F. Sotty
  • et al

Differential Effects of lntrastriatal Neurotensin(1–13) and Neurotensin(8–13) on Striatal Dopamine and Pallidal GABA Release. A Dual-probe Microdialysis Study in the Awake Rat

Eur. J. Neurosci . 2006 Apr 07 ; 9(9) 1838 | DOI :

  • L. Ferraro
  • et al

Xenopsin, neurotensin, neurotensin(8-13) and N-acetyl-neurotensin(8-13) inhibit vascular leakage in rats after tissue injury

J Pharmacol Exp Ther . 1993 May 01 ; 265(2) 619 | DOI : PMID: 8496813

  • G. Gao
  • E. Wei